Home Transmembrane Transporters Calcium Channel chemical - PKC activator Ionomycin For research use only.

Ionomycin

Synonyms: SQ23377

Ionomycin (SQ23377) is a potent and selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. It induces the activation of protein kinase C (PKC) and promotes apoptosis.

Ionomycin Chemical Structure

Ionomycin Chemical Structure

CAS No. 56092-81-0

Purity & Quality Control

Batch: S707401 DMSO]100 mg/mL]false]Ethanol]100 mg/mL]false]]]false Purity: 99%
99

Ionomycin Related Products

Signaling Pathway

Calcium Channel Signaling Pathways

Calcium Channel Signaling Pathway

Biological Activity

Description Ionomycin (SQ23377) is a potent and selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. It induces the activation of protein kinase C (PKC) and promotes apoptosis.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02686827 Completed
Hypersensitivity
Laurian Jongejan|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 October 2015 Phase 2
NCT00657891 Completed
Asthma
Creighton University|Novartis Pharmaceuticals
 March 2007 Phase 4

Chemical Information & Solubility

Molecular Weight 709.01 Formula

C41H72O9
CAS No. 56092-81-0 SDF --
Smiles CC(CCC(=O)O)CC(C)CC(C)C(=O)C=C(C(C)CC(C)CC=CC(C)C(C(C)C(CC1CCC(O1)(C)C2CCC(O2)(C)C(C)O)O)O)O
Storage (From the date of receipt) 2 years -80 in solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (141.04 mM) Ultrasonicated; Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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