Home Transmembrane Transporters Calcium Channel inhibitor Zegocractin (CM 4620) For research use only.

Zegocractin (CM 4620)

Zegocractin (CM 4620) is an inhibitor of calcium-release activated calcium-channel (CRAC channel). CM4620 inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of near 120 nM and 900 nM, respectively.

Zegocractin (CM 4620) Chemical Structure

Zegocractin (CM 4620) Chemical Structure

CAS No. 1713240-67-5

Purity & Quality Control

Zegocractin (CM 4620) Related Products

Signaling Pathway

Calcium Channel Signaling Pathways

Calcium Channel Signaling Pathway

Biological Activity

Description Zegocractin (CM 4620) is an inhibitor of calcium-release activated calcium-channel (CRAC channel). CM4620 inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of near 120 nM and 900 nM, respectively.
Targets
Orai1/STIM1-mediated Ca2+ currents [1]
(Cell-free assay)		 Orai2/STIM1-mediated currents [1]
(Cell-free assay)
120 nM 900 nM
In vitro
In vitro

CM4620 inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of near 120 nM and 900 nM, respectively.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04661540 Completed
Pneumonia
CalciMedica Inc.|Northwestern University
 March 2 2021 Phase 2
NCT04195347 Recruiting
Acute Pancreatitis
St. Jude Children''s Research Hospital|CalciMedica Inc.
 September 4 2020 Phase 1|Phase 2
NCT04345614 Completed
Pneumonia
CalciMedica Inc.
 April 8 2020 Phase 2
NCT03709342 Completed
Acute Pancreatitis
CalciMedica Inc.
 January 6 2019 Phase 2

Chemical Information & Solubility

Molecular Weight 421.76 Formula

C19H11ClF3N3O3
CAS No. 1713240-67-5 SDF --
Smiles CC1=C(C(=CC=C1)F)C(=O)NC2=NC=C(N=C2)C3=CC4=C(C=C3Cl)OC(O4)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (237.1 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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