Home Transmembrane Transporters Calcium Channel activator Bay K 8644 For research use only.

Bay K 8644

Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.

Bay K 8644 Chemical Structure

Bay K 8644 Chemical Structure

CAS No. 71145-03-4

Purity & Quality Control

Bay K 8644 Related Products

Signaling Pathway

Calcium Channel Signaling Pathways

Calcium Channel Signaling Pathway

Biological Activity

Description Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.
Targets
L-type calcium channel [1]
(in the isolated field-stimulated vas deferens of the mouse)
17.3nM(EC50)
In vitro
In vitro

Bay K 8644 increases resting tension in segments of mesenteric arteries isolated from young and old rats as an agonist of L-type Ca2+ channel[2]
Cell Research Cell lines 5TGM1 cells
Concentrations 10 nM
Incubation Time 30 minutes
Method

Cells were treated with indicated concentration of drug for 30 minutes.
In Vivo
In vivo

Bay K 8644 induces small contractions in aortae from Wistar-Kyoto(WKY) rats of 5-week-, 3-month-, 1-year-, 1.5-year-old, which are unaltered with age.[3]
Animal Research Animal Models Male Sprague-Dawley rats
Dosages 1, 10, 50 and 100 µg/kg
Administration Jugular catheters

Chemical Information & Solubility

Molecular Weight 356.30 Formula

C16H15F3N2O4
CAS No. 71145-03-4 SDF Download Bay K 8644 SDF
Smiles CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 71 mg/mL ( (199.27 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 71 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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