Home Cell Cycle CDK inhibitor Palbociclib 2HCL For research use only.

Palbociclib 2HCL

Synonyms: PD-0332991 dihydrochloride

Palbociclib 2HCL (PD-0332991 dihydrochloride), the dihydrochloride salt of Palbociclib, is a highly specific inhibitor of Cdk4 and Cdk6, with IC50 values of 11 nM and 16 nM, respectively. It is a potent antiproliferative agent against retinoblastoma (Rb)-positive tumor cells in vitro, inducing a selective G1 cell cycle arrest and reducing phosphorylation at Ser780 and Ser795 on the Rb protein.

Palbociclib 2HCL Chemical Structure

Palbociclib 2HCL Chemical Structure

CAS No. 571189-11-2

Purity & Quality Control

Batch: E602501 DMSO]97 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.90%
99.90

Palbociclib 2HCL Related Products

Signaling Pathway

CDK Signaling Pathways

CDK Signaling Pathway

Biological Activity

Description Palbociclib 2HCL (PD-0332991 dihydrochloride), the dihydrochloride salt of Palbociclib, is a highly specific inhibitor of Cdk4 and Cdk6, with IC50 values of 11 nM and 16 nM, respectively. It is a potent antiproliferative agent against retinoblastoma (Rb)-positive tumor cells in vitro, inducing a selective G1 cell cycle arrest and reducing phosphorylation at Ser780 and Ser795 on the Rb protein.

Chemical Information & Solubility

Molecular Weight 520.5 Formula

C24H31Cl2N7O2
CAS No. 571189-11-2 SDF Download Palbociclib 2HCL SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 97 mg/mL ( (186.35 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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