Home DNA Damage/DNA Repair Sirtuin inhibitor NRD167 For research use only.

NRD167

Synonyms: Et-29

NRD167 is a potent and selective SIRT5 inhibitor.

NRD167 Chemical Structure

NRD167 Chemical Structure

CAS No. 2166487-23-4

Purity & Quality Control

NRD167 Related Products

Signaling Pathway

Sirtuin Signaling Pathways

Sirtuin Signaling Pathway

Biological Activity

Description

NRD167 is a potent and selective SIRT5 inhibitor.
Targets
SIRT5 [1]
In vitro
In vitro

NRD167 can selectively inhibit cell proliferation, metabolism, and colony formation of AML Cells by inhibiting SIRT5. [2]
Cell Research Cell lines AML cell lines
Concentrations 5 μΜ, 10 μΜ, 20 μΜ
Incubation Time 72 h
Method

 Viable cells are measured using CellTiter 96 AQueous One Solution MTS Reagent for Cell Proliferation Assays.  Colonies are counted 7 to 10 days after planting.

Chemical Information & Solubility

Molecular Weight 666.83 Formula

C34H46N6O6S
CAS No. 2166487-23-4 SDF --
Smiles CCOC(=O)CCNC(=S)NCCCCC(NC(=O)OCC1=CC=CC=C1)C(=O)NC(CC2=C[NH]C3=C2C=CC=C3)C(=O)NC(C)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (149.96 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 30 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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