NRD167

Catalog No.S9903 Batch:S990303

Print

Technical Data

Formula

C34H46N6O6S
Molecular Weight 666.83 CAS No. 2166487-23-4
Solubility (25°C)* In vitro DMSO 100 mg/mL (149.96 mM)
Ethanol 30 mg/mL (44.98 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description

NRD167 is a potent and selective SIRT5 inhibitor.
Targets
SIRT5 [1]
In vitro

NRD167 can selectively inhibit cell proliferation, metabolism, and colony formation of AML Cells by inhibiting SIRT5. [2]

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    AML cell lines

  • Concentrations

    5 μΜ, 10 μΜ, 20 μΜ

  • Incubation Time

    72 h

  • Method

     Viable cells are measured using CellTiter 96 AQueous One Solution MTS Reagent for Cell Proliferation Assays.  Colonies are counted 7 to 10 days after planting.

Selleck's NRD167 has been cited by 4 publications

Sirtuin 5-driven meiotic spindle assembly and actin-based migration in mouse oocyte meiosis [ Heliyon, 2024, 10(11):e32466] PubMed: 38933958
Gravitational and mechanical forces drive mitochondrial translation [ bioRxiv, 2024, 10.1101/2023.01.18.524628] PubMed: none
Core-predominant gut fungus Kazachstania slooffiae promotes intestinal epithelial glycolysis via lysine desuccinylation in pigs [ Microbiome, 2023, 11(1):31] PubMed: 36814349
TFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis [ EMBO J, 2022, e110324] PubMed: 35451091

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.