Home Epigenetics Sirtuin activator UBCS039 For research use only.

UBCS039

UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.

UBCS039 Chemical Structure

UBCS039 Chemical Structure

CAS No. 358721-70-7

Purity & Quality Control

Batch: S890901 DMSO]49 mg/mL]false]Ethanol]16 mg/mL]false]Water]Insoluble]false Purity: 99.82%
99.82

UBCS039 Related Products

Signaling Pathway

Sirtuin Signaling Pathways

Sirtuin Signaling Pathway

Biological Activity

Description UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.
Targets
SIRT6 [1]
(Cell-free assay)
38 μM(EC50)
In vitro
In vitro

UBCS039 induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells.UBCS039 leads to autophagosome accumulation and induces autophagic flux in human cancer cells.UBCS039 also induces autophagy-associated cell death.[1]
Cell Research Cell lines HeLa cells
Concentrations 100 µM
Incubation Time 24 h
Method

HeLa cells are treated with 100 µM UBCS039 for 24 h, harvested, washed in PBS 1× and stained for 30 min at 37 °C with dihydroethidium 50 µM dissolved in DMEM without fetal bovine serum.

Chemical Information & Solubility

Molecular Weight 247.29 Formula

C16H13N3
CAS No. 358721-70-7 SDF --
Smiles C1=CC=C2C(=C1)NC(C3=CC=CN32)C4=CN=CC=C4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 49 mg/mL ( (198.14 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 16 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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