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Inauhzin Sirtuin inhibitor

Cat.No.S6744

Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.
Inauhzin Sirtuin inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 469.58

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Quality Control

Batch: S674401 DMSO]94 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.66%
99.66

Solubility

In vitro
Batch:

DMSO : 94 mg/mL (200.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 469.58 Formula

C25H19N5OS2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 309271-94-1 -- Storage of Stock Solutions

Synonyms N/A Smiles CCC(C(=O)N1C2=CC=CC=C2SC3=CC=CC=C31)SC4=NC5=C(C6=CC=CC=C6N5)N=N4

Mechanism of Action

Targets/IC50/Ki
SIRT1
p53
In vitro

Inauhzin (INZ) is a potent p53 activator and mediates p53-dependent cytotoxicity. This compound inhibits cell proliferation by triggering both apoptosis and senescence in p53-containning cells, though it predominantly induces p53-dependent apoptosis. It is able to prevent p53 from MDM2-mediated ubiquitylation and proteasomal degradation and protects p53 without either directly inhibiting MDM2 activity towards p53 or interfering with MDMX/MDM2–p53 interaction. This chemical induces acetylation of p53, but not tubulin, in cells. It is a (sub)micromolar SIRT1i selective over SIRT2/3.
In vivo

Inauhzin (INZ) has good tumour tissue penetration and is able to inhibit tumour growth by inducing p53.
References

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