SIRT2 Selective Inhibitors

Catalog No.	Product Name	Information	Selective / Pan	IC50 / Ki
S2176	Tenovin-3	Tenovin-3 is an inhibitor of SIRT2. Tenovin-3 is able to increase p53 levels in MCF-7 cells.	Selective
S8245	Thiomyristoyl	Thiomyristoyl (TM) is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.	Selective	SIRT2, IC50: 28 nM
S7845	SirReal2	SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.	Selective	SIRT2, IC50: 140 nM
S7577	AGK2	AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.	Selective	SIRT2, IC50: 3.5 μM
S5914	AK 7	AK 7 is a brain-permeable selective SIRT2 inhibitor with an IC50 of 15.5 μM.	Selective	SIRT2, IC50: 15.5 μM
S8628	3-TYP	3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.	Pan	SIRT2, IC50: 92 nM
S8942	Suramin sodium salt	Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatase (PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).	Pan	SirT2, IC50: 1.15 μM
S4900	Tenovin-6	Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2.	Pan	SIRT2, IC50: 10 μM
S2804	Sirtinol	Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.	Pan	SIRT2, IC50: 38 μM
S8627	OSS_128167	OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.	Pan	SIRT2, IC50: 751 μM
S1396	Resveratrol	Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.	Pan
S8460	Salermide	Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.	Pan