Home Apoptosis p53 activator - Dehydrogenase inhibitor - Sirtuin inhibitor Tenovin-6 For research use only.

Tenovin-6

Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2.

Tenovin-6 Chemical Structure

Tenovin-6 Chemical Structure

CAS No. 1011557-82-6

Size Price Stock Quantity
5mg USD 90 In stock
25mg USD 270 In stock
Bulk Size Bulk Discount

Free Delivery on orders over USD 500. Order now.
Selleck USA

Tel: (832) 582-8158

sales@selleckchem.com

Purity & Quality Control

Batch: S490001 DMSO]98 mg/mL]false]Water]98 mg/mL]false]Ethanol]Insoluble]false Purity: 99.68%
99.68

Tenovin-6 Related Products

Signaling Pathway

p53 Signaling Pathways

p53 Signaling Pathway

Biological Activity

Description Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2.
Targets
DHODH [2] p53 [1] SIRT2 [1] SIRT1 [1] SIRT3 [1]
10 μM 21 μM 67 μM
In vitro
In vitro

Tenovin-6 is a more water-soluble analog of tenovin-1. Tenovin-6 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 of 21 μM, 10 μM, and 67 μM, respectively. [1]

Chemical Information & Solubility

Molecular Weight 454.63 Formula

C25H34N4O2S
CAS No. 1011557-82-6 SDF Download Tenovin-6 SDF
Smiles CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 98 mg/mL ( (215.55 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 98 mg/mL

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator
Clear solution
5%DMSO 40% 5% 50%ddH2O
4.9mg/ml (10.78mM) Taking the 1 mL working solution as an example, add 50 μL of 98 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Tenovin-6 | Tenovin-6 supplier | purchase Tenovin-6 | Tenovin-6 cost | Tenovin-6 manufacturer | order Tenovin-6 | Tenovin-6 distributor