Home Apoptosis p53 inhibitor ReACp53 For research use only.

ReACp53

ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC).

ReACp53 Chemical Structure

ReACp53 Chemical Structure

CAS No. unknown

Purity & Quality Control

ReACp53 Related Products

Signaling Pathway

p53 Signaling Pathways

p53 Signaling Pathway

Biological Activity

Description ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC).
Targets
p53 amyloid formation [1]
In vitro
In vitro

ReACp53 rescues p53 transcription of target genes and restores apoptosis. Rescued p53 behaves similarly to its wild-type counterpart in regulating target genes, reducing cell proliferation and increasing cell death[1].
Cell Research Cell lines S1 GODL cells
Concentrations 5 μM
Incubation Time 16 h
Method

Cells were treated with various concentrations of drug for 16 h.
In Vivo
In vivo

ReACp53 halts progression and shrinks tumors bearing aggregation-prone p53[1].

Chemical Information & Solubility

Molecular Weight 2617.13 Formula

C108H206N52O24
CAS No. unknown SDF Download ReACp53 SDF
Smiles CCC(C)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1CCCN1C(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(N)CCCNC(N)=N)C(C)CC)C(C)O)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(O)=O
Storage (From the date of receipt)

In vitro
Batch:

Water : 100 mg/mL

DMSO : 10 mg/mL ( (3.82 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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