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Technical Data
| Formula | C108H206N52O24 |
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| Molecular Weight | 2617.13 | CAS No. | unknown | |
| Solubility (25°C)* | In vitro | Water | 100 mg/mL (38.2 mM) | |
| DMSO | 10 mg/mL (3.82 mM) | |||
| Ethanol | 10 mg/mL (3.82 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC). | |
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| In vitro | ReACp53 rescues p53 transcription of target genes and restores apoptosis. Rescued p53 behaves similarly to its wild-type counterpart in regulating target genes, reducing cell proliferation and increasing cell death[1]. |
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| In vivo | ReACp53 halts progression and shrinks tumors bearing aggregation-prone p53[1]. |
Protocol (from reference)
| Cell Assay: |
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Selleck's ReACp53 has been cited by 2 publications
| Cytoplasmic p53 aggregates accumulated in p53-mutated cancer correlate with poor prognosis [ PNAS Nexus, 2022, 1(3):pgac128] | PubMed: 36741442 |
| Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function [ Nat Commun, 2021, 12(1):3962] | PubMed: 34172723 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.