Home Neuronal Signaling Adrenergic Receptor agonist (−)-Norepinephrine For research use only.

(−)-Norepinephrine

Synonyms: Arterenol, Levarterenol, L-Noradrenaline

(−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.

(−)-Norepinephrine Chemical Structure

(−)-Norepinephrine Chemical Structure

CAS No. 51-41-2

Purity & Quality Control

(−)-Norepinephrine Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description (−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.
Targets
α2A adrenoceptor [1]
(CHO-C10 cells)		 α1 adrenoceptor [1]
(cell-based assay)		 β1 adrenoceptor [1]
(cell-based assay)
56 nM(Ki) 330 nM(Ki) 740 nM(Ki)
In vitro
In vitro

(-)-Norepinephrine inhibits the production of TNF-α, IL-6, and CXCL2/MIP-2 and promotes the secretion of IL-10 from LPS-stimulated murine alveolar macrophages. (-)-Norepinephrine down-regulates NF-κB activation in stimulated alveolar macrophages. [2]
In Vivo
In vivo

Injection of (-)-Norepinephrine into senescence-accelerated prone 8 (SAMP8) mice reverses formaldehyde accumulation and (-)-Norepinephrine deficiency and restored the magnitude of long-term potentiation and memory. [3]

Chemical Information & Solubility

Molecular Weight 169.18 Formula

C8H11NO3
CAS No. 51-41-2 SDF --
Storage (From the date of receipt) 3 years -20°C(in the dark) powder
1 year -80°C(in the dark) in solvent

In vitro
Batch:

DMSO : 3 mg/mL ( (17.73 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy (−)-Norepinephrine | (−)-Norepinephrine ic50 | (−)-Norepinephrine price | (−)-Norepinephrine cost | (−)-Norepinephrine solubility dmso | (−)-Norepinephrine purchase | (−)-Norepinephrine manufacturer | (−)-Norepinephrine research buy | (−)-Norepinephrine order | (−)-Norepinephrine mouse | (−)-Norepinephrine chemical structure | (−)-Norepinephrine mw | (−)-Norepinephrine molecular weight | (−)-Norepinephrine datasheet | (−)-Norepinephrine supplier | (−)-Norepinephrine in vitro | (−)-Norepinephrine cell line | (−)-Norepinephrine concentration | (−)-Norepinephrine nmr