Home GPCR & G Protein Adrenergic Receptor agonist - CRISPR/Cas9 activator L755507 For research use only.

L755507

L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.

L755507 Chemical Structure

L755507 Chemical Structure

CAS No. 159182-43-1

Purity & Quality Control

Batch: S797401 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.06%
99.06

L755507 Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.
Targets
β3 adrenergic receptor [1]
0.43 nM(EC50)
In vitro
In vitro L-755,507 displays an excellent activity profile as an extremely potent human β3 adrenergic receptor agonist (β3 EC50 0.43 nM), with >440-fold selectivity over β1 and β2 binding[1]. L755507 causes a robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human β3-adrenoceptors(pEC50 values of 12.3)[4]. In a recent study employing a high-throughput screen to identify chemicals capable of modulating HR-mediated genome editing, L-755507 is identified that could enhance HR repair by up to ninefold[3].
Cell Research Cell lines cancer cell lines(K562 and HeLa), suspension cells (K562), primary neonatal cells (HUVEC and fibroblast CRL-2097), and human ESC derived cells (neural stem cells)
Concentrations 5 μM
Incubation Time 24 hours
Method

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In Vivo
In vivo Acute exposure of rhesus monkeys to L-755,507 elicits lipolysis and metabolic rate elevation, and that chronic exposure increases uncoupling protein 1 expression in rhesus brown adipose tissue[2].
Animal Research Animal Models Male lean rhesus monkeys
Dosages 3 mg/kg
Administration i.v.

Chemical Information & Solubility

Molecular Weight 584.73 Formula

C30H40N4O6S
CAS No. 159182-43-1 SDF Download L755507 SDF
Smiles CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (171.01 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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