Home Neuronal Signaling Adrenergic Receptor agonist Medetomidine HCl For research use only.

Medetomidine HCl

Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.

Medetomidine HCl Chemical Structure

Medetomidine HCl Chemical Structure

CAS No. 86347-15-1

Purity & Quality Control

Batch: S306001 Water]47 mg/mL]false]Ethanol]47 mg/mL]false]DMSO]12 mg/mL]false Purity: 99.92%
99.92

Medetomidine HCl Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.
Targets
α2-adrenoceptor [1]
1.08 nM(Ki)
In vitro
In vitro Medetomidine is a selectiveα2-adrenoceptor agonist, with Ki of 1.08 nM, exhibits 1620-fold selectivity over α1-adrenoceptor, has very weak or no binding to other neurotransmitter receptors. [1]
In Vivo
In vivo In anesthetized rats, medetomidine (1-100 μg/kg, i.v.) induces a dose-dependent, relatively short-lived reduction in blood pressure and heart rate. In the pithed rat, medetomidine shows very potent vasopressor (PD50 1.7 μg/kg) and sympatho-inhibitory (ID50 1.6 μg/kg) effects without affecting basal heart rate. [2] Medetomidine induces dose-dependent sedation, which at high doses (>100μg/kg) includes loss of the righting reflex and hypothermia. Medetomidine induces a decreases in the turnover rate of biogenic amines in the brain, dose-dependently inhibits norepinephrine (NE) turnover, inhibits brain dopamine turnover at high doses, decreases serotonin turnover. [3]
Animal Research Animal Models Rat
Dosages 1-100 μg/kg
Administration i.v.

Chemical Information & Solubility

Molecular Weight 236.74 Formula

C13H16N2.HCl
CAS No. 86347-15-1 SDF Download Medetomidine HCl SDF
Smiles CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 47 mg/mL

Ethanol : 47 mg/mL

DMSO : 12 mg/mL ( (50.68 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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