Home Neuronal Signaling Adrenergic Receptor antagonist Yohimbine HCl For research use only.

Yohimbine HCl

Synonyms: Antagonil

Yohimbine (Antagonil) has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.

Yohimbine HCl Chemical Structure

Yohimbine HCl Chemical Structure

CAS No. 65-19-0

Purity & Quality Control

Yohimbine HCl Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Yohimbine (Antagonil) has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
Targets
alpha 2-adrenergic receptor [2]
In vitro
In vitro Yohimbine(Antagonil) has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac. [1] Yohimbine is a pre-synaptic alpha 2-adrenergic blocking agent. Yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephrine release and in firing rate of cells in the brain noradrenergic nuclei. [2]
In Vivo
In vivo LD50: Mice 55mg/kg (i.p.) [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04346394 Withdrawn
Parkinson Disease
Nathaniel M. Robbins|Dartmouth-Hitchcock Medical Center
 May 11 2021 Early Phase 1
NCT04051619 Completed
Opioid Use Disorder
Brown University
 January 6 2020 Phase 1
NCT00605904 Completed
Alcoholism
National Institute on Alcohol Abuse and Alcoholism (NIAAA)|National Institutes of Health Clinical Center (CC)
 January 2008 Phase 2
NCT00000196 Withdrawn
Opioid-Related Disorders
Yale University|National Institute on Drug Abuse (NIDA)
 January 1993 Phase 2

Chemical Information & Solubility

Molecular Weight 390.9 Formula

C21H26N2O3.HCl
CAS No. 65-19-0 SDF Download Yohimbine HCl SDF
Smiles COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 16 mg/mL ( (40.93 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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