Home Neuronal Signaling Adrenergic Receptor chemical Deoxycorticosterone acetate For research use only.

Deoxycorticosterone acetate

Synonyms: 11-Deoxycorticosterone acetate, DOC acetate, Cortexone acetate

Deoxycorticosterone acetate (11-Deoxycorticosterone, DOC, Cortexone) is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.

Deoxycorticosterone acetate Chemical Structure

Deoxycorticosterone acetate Chemical Structure

CAS No. 56-47-3

Purity & Quality Control

Deoxycorticosterone acetate Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Deoxycorticosterone acetate (11-Deoxycorticosterone, DOC, Cortexone) is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.
In Vivo
In vivo Deoxycorticosterone acetate (DOCA) is an agent commonly used to induce hypertension in experimental animals. This form of hypertension is dependent on altered regulation of central pressor mechanisms including the brain renin-angiotensin system.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05633953 Completed
Cushing''s Syndrome
RECORDATI GROUP
 January 16 2023 --
NCT01331239 Completed
Cushings Disease|Cushing Disease
Novartis Pharmaceuticals|Novartis
 March 23 2011 Phase 2
NCT01186484 Completed
Prostatic Neoplasms
Janssen Pharmaceutical K.K.
 June 1 2010 Phase 1

Chemical Information & Solubility

Molecular Weight 372.5 Formula

C23H32O4
CAS No. 56-47-3 SDF Download Deoxycorticosterone acetate SDF
Smiles CC(=O)OCC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 11 mg/mL ( (29.53 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 6 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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