Home Neuronal Signaling Adrenergic Receptor agonist Higenamine hydrochloride For research use only.

Higenamine hydrochloride

Synonyms: Norcoclaurine HCl, (+-)-Demethylcoclaurine hydrochloride

Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.

Higenamine hydrochloride Chemical Structure

Higenamine hydrochloride Chemical Structure

CAS No. 11041-94-4

Purity & Quality Control

Batch: S396001 DMSO]61 mg/mL]false]]]false]]]false Purity: 99.32%
99.32

Higenamine hydrochloride Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.
Targets
β2-adrenoceptor [1] α1-adrenoceptor [1]
In vitro
In vitro Higenamine is a potential β2-adrenoceptor agonist. As a potent cardiotonic and vasodilator, It is also an α1 antagonist and a weak α2 agonist[1]. Higenamine decreases the intracellular dopamine content dose-dependently and shows 55.2% inhibition of dopamine content in PC12 cells at a concentration of 2OM with 24h incubation. The IC50 value of higenamine for inhibiting dopamine biosynthesis in PC12 cells is 18.2 μM. Dopamine content is lowered and reaches minimal level at 12—24h after exposure to higenamine[2].
Cell Research Cell lines PC12 cells
Concentrations 5-20 μM
Incubation Time 12-48 h
Method

PC12 cells are maintained routinely in RPMI 1640 medium supplemented with 10% heat-inactivated horse serum and 5 % fetal calf serum pius 100 units/ml penicillin and 100 μg/ml streptomycin at 37°C. The PC12 cells (ca. 1×105 cells/cm2) are treated with higenamine (5-2O μM) and then incubated for 12 (-48) h. The cells (ca. 1.5-2 × 105 cells/cm2) are harvested with phosphate buffered saline (PBS) and the pellet extract is used for the measurement of dopamine content, and TH and AADC activities.
In Vivo
In vivo Higenamine can produce relaxation in tracheal muscle[1]. Higenamine has anti-thrombotic effects in both mouse acute thrombosis model and rat arterio-venous shunt (AV-shunt) models. The oral administration of higenamine (50 or 100 mg/kg) increases the recovery rates from the acute thrombotic challenge in mice and lowers the weight of thrombus formed inside the AV-shunt tube in rats[3].
Animal Research Animal Models mice
Dosages 50 or 100 mg/kg
Administration oral

Chemical Information & Solubility

Molecular Weight 307.77 Formula

C16H17NO3.HCl
CAS No. 11041-94-4 SDF --
Smiles C1CNC(C2=CC(=C(C=C21)O)O)CC3=CC=C(C=C3)O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 61 mg/mL ( (198.19 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Tech Support

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