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Technical Data
| Formula | C8H11NO3 |
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| Molecular Weight | 169.18 | CAS No. | 51-41-2 | |
| Solubility (25°C)* | In vitro | DMSO | 11 mg/mL (65.01 mM) | |
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | (−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively. | ||||||
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| Targets |
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| In vitro | (-)-Norepinephrine inhibits the production of TNF-α, IL-6, and CXCL2/MIP-2 and promotes the secretion of IL-10 from LPS-stimulated murine alveolar macrophages. (-)-Norepinephrine down-regulates NF-κB activation in stimulated alveolar macrophages. [2] |
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| In vivo | Injection of (-)-Norepinephrine into senescence-accelerated prone 8 (SAMP8) mice reverses formaldehyde accumulation and (-)-Norepinephrine deficiency and restored the magnitude of long-term potentiation and memory. [3] |
Protocol (from reference)
References
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Selleck's (−)-Norepinephrine has been cited by 5 publications
| Generation of self-organized autonomic ganglion organoids from fibroblasts [ iScience, 2023, 26(3):106241] | PubMed: 36922996 |
| Suppression of trabecular meshwork phagocytosis by norepinephrine is associated with nocturnal increase in intraocular pressure in mice [ Commun Biol, 2022, 5(1):339] | PubMed: 35396348 |
| Inhibition of STAT3 enhances UCP1 expression and mitochondrial function in brown adipocytes [ Eur J Pharmacol, 2022, 926:175040] | PubMed: 35598846 |
| α2A-adrenoceptor deficiency attenuates lipopolysaccharide-induced lung injury by increasing norepinephrine levels and inhibiting alveolar macrophage activation in acute respiratory distress syndrome [ Clin Sci (Lond), 2020, 134(14):1957-1971] | PubMed: 32643759 |
| Berberine Attenuates Cardiac Hypertrophy Through Inhibition of mTOR Signaling Pathway [ Cardiovasc Drugs Ther, 2020, 11] | PubMed: 32394178 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.