(−)-Norepinephrine

Catalog No.S9507 Batch:S950702

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Technical Data

Formula

C8H11NO3
Molecular Weight 169.18 CAS No. 51-41-2
Solubility (25°C)* In vitro DMSO 11 mg/mL (65.01 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 95% Corn oil
0.55mg/ml Taking the 1 mL working solution as an example, add 50 μL of 11 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
0.55mg/ml Taking the 1 mL working solution as an example, add 50 μL of 11 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description (−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.
Targets
α2A adrenoceptor [1]
(CHO-C10 cells)		 α1 adrenoceptor [1]
(cell-based assay)		 β1 adrenoceptor [1]
(cell-based assay)
56 nM(Ki) 330 nM(Ki) 740 nM(Ki)
In vitro

(-)-Norepinephrine inhibits the production of TNF-α, IL-6, and CXCL2/MIP-2 and promotes the secretion of IL-10 from LPS-stimulated murine alveolar macrophages. (-)-Norepinephrine down-regulates NF-κB activation in stimulated alveolar macrophages. [2]
In vivo

Injection of (-)-Norepinephrine into senescence-accelerated prone 8 (SAMP8) mice reverses formaldehyde accumulation and (-)-Norepinephrine deficiency and restored the magnitude of long-term potentiation and memory. [3]

Protocol (from reference)

Selleck's (−)-Norepinephrine has been cited by 5 publications

Generation of self-organized autonomic ganglion organoids from fibroblasts [ iScience, 2023, 26(3):106241] PubMed: 36922996
Suppression of trabecular meshwork phagocytosis by norepinephrine is associated with nocturnal increase in intraocular pressure in mice [ Commun Biol, 2022, 5(1):339] PubMed: 35396348
Inhibition of STAT3 enhances UCP1 expression and mitochondrial function in brown adipocytes [ Eur J Pharmacol, 2022, 926:175040] PubMed: 35598846
α2A-adrenoceptor deficiency attenuates lipopolysaccharide-induced lung injury by increasing norepinephrine levels and inhibiting alveolar macrophage activation in acute respiratory distress syndrome [ Clin Sci (Lond), 2020, 134(14):1957-1971] PubMed: 32643759
Berberine Attenuates Cardiac Hypertrophy Through Inhibition of mTOR Signaling Pathway [ Cardiovasc Drugs Ther, 2020, 11] PubMed: 32394178

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.