Home Cell Cycle CDK inhibitor Dalpiciclib For research use only.

Dalpiciclib

Synonyms: SHR-6390

Dalpiciclib (SHR-6390), a highly selective, orally bioavailable CDK4/6 inhibitor with comparable potencies against CDK4 and CDK6, exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated tumor-suppressor retinoblastoma protein (Rb) and inducing G1 cell cycle arrest. This product has poor solubility, animal experiments are available, cell experiments please choose carefully!

Dalpiciclib Chemical Structure

Dalpiciclib Chemical Structure

CAS No. 1637781-04-4

Purity & Quality Control

Dalpiciclib Related Products

Signaling Pathway

CDK Signaling Pathways

CDK Signaling Pathway

Biological Activity

Description Dalpiciclib (SHR-6390), a highly selective, orally bioavailable CDK4/6 inhibitor with comparable potencies against CDK4 and CDK6, exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated tumor-suppressor retinoblastoma protein (Rb) and inducing G1 cell cycle arrest. This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
Targets
CDK6 [1] CDK4 [1]
9.9 nM 12.4 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05515289 Recruiting
Breast Cancer
Jiangsu HengRui Medicine Co. Ltd.
 December 18 2022 Phase 1
NCT05586841 Not yet recruiting
HR+/HER2- Advanced Breast Cancer
Beijing 302 Hospital
 November 1 2022 Phase 1

Chemical Information & Solubility

Molecular Weight 446.54 Formula

C25H30N6O2
CAS No. 1637781-04-4 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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