Home DNA Damage/DNA Repair HDAC inhibitor - Autophagy modulator 4-PBA (4-Phenylbutyric acid) For research use only.

4-PBA (4-Phenylbutyric acid)

Synonyms: Benzenebutyric acid

4-PBA (4-Phenylbutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models.

4-PBA (4-Phenylbutyric acid) Chemical Structure

4-PBA (4-Phenylbutyric acid) Chemical Structure

CAS No. 1821-12-1

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4-PBA (4-Phenylbutyric acid) Related Products

Signaling Pathway

HDAC Signaling Pathways

HDAC Signaling Pathway

Biological Activity

Description 4-PBA (4-Phenylbutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models.
Targets
HDAC [1]
In vitro
In vitro

4-PBA inhibits the ER stress induced by SiNPs in RAW264.7 cells, as evidenced by the expansion and degranulation of ER, as well as greatly up-regulated Bip and CHOP expressions.[3]
Cell Research Cell lines Mouse macrophage cell line, RAW264.7 cells
Concentrations 3 mM
Incubation Time 6 h
Method

Mouse macrophage cell line, RAW264.7 cells are cultured in DMEM with 10% fetal bovine serum at 37 ℃ in a 5% CO2 incubator. SiNPs are diluted by DMEM to appropriate concentrations, and an ER stress inhibitor, 4-phenylbutyric acid (4-PBA) is applied (3 mM, 6 h). The SiNPs-treated group is at a concentration of 50 μg/ml in vitro experiments. Similarly, the application of 4-PBA is set up through MTT assay, after SiNPs with or without 4-PBA treatment, cells are harvested for the following measurement. The levels of Bip and CHOP induced by SiNPs are measured.
In Vivo
In vivo

4-PBA attenuates LPS-induced bone loss in lipopolysaccharide (LPS)-treated mice, by increasing area of TRAP-positive osteoclasts (OCs) and serum level of collagen type I fragments.[4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00067756 Completed
Alpha 1-Antitrypsin Deficiency
University of Florida|Alpha-1 Foundation|Brantly Mark L. M.D.
 November 2001 Phase 2

Chemical Information & Solubility

Molecular Weight 164.20 Formula

C10H12O2
CAS No. 1821-12-1 SDF --
Smiles OC(=O)CCCC1=CC=CC=C1
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 33 mg/mL ( (200.97 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 33 mg/mL

Water : Insoluble


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