Home DNA Damage/DNA Repair HDAC inhibitor ACY-775 For research use only.

ACY-775

ACY-775 is a potent and selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.5  nM.

ACY-775 Chemical Structure

ACY-775 Chemical Structure

CAS No. 1375466-18-4

Purity & Quality Control

ACY-775 Related Products

Signaling Pathway

HDAC Signaling Pathways

HDAC Signaling Pathway

Biological Activity

Description ACY-775 is a potent and selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.5  nM.
Targets
HDAC6 [1]
(Cell-free assay)
7.5 nM
In vitro
In vitro

ACY-775 is a potent and selective histone deacetylase 6 (HDAC6) inhibitor.
Cell Research Cell lines RN46A-B14 cells
Concentrations 2.5 μM
Incubation Time 4 h
Method

Cells were treated with 2.5 μM ACY-775 or vehicle (0.1% DMSO) for 4 h.

Chemical Information & Solubility

Molecular Weight 330.36 Formula
C17H19FN4O2
CAS No. 1375466-18-4 SDF --
Smiles ONC(=O)C1=CN=C(NC2(CCCCC2)C3=CC(=CC=C3)F)N=C1
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 66 mg/mL ( (199.78 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 66 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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