ACY-775

Catalog No.S0864 Batch:S086403

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Technical Data

Formula
C17H19FN4O2
Molecular Weight 330.36 CAS No. 1375466-18-4
Solubility (25°C)* In vitro DMSO 66 mg/mL (199.78 mM)
Ethanol 66 mg/mL (199.78 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
3.3mg/ml Taking the 1 mL working solution as an example, add 50 μL 66 mg/ml clarified DMSO stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description ACY-775 is a potent and selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.5  nM.
Targets
HDAC6 [1]
(Cell-free assay)
7.5 nM
In vitro

ACY-775 is a potent and selective histone deacetylase 6 (HDAC6) inhibitor.

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    RN46A-B14 cells

  • Concentrations

    2.5 μM

  • Incubation Time

    4 h

  • Method

    Cells were treated with 2.5 μM ACY-775 or vehicle (0.1% DMSO) for 4 h.
Animal Study:

[2]
  • Animal Models

    Male NIH Swiss mice

  • Dosages

    50 mg/kg

  • Administration

    i.p.

Selleck's ACY-775 has been cited by 2 publications

Unveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma [ J Exp Clin Cancer Res, 2024, 43(1):152] PubMed: 38812060
Selectivity of Hydroxamate- and Difluoromethyloxadiazole-Based Inhibitors of Histone Deacetylase 6 In Vitro and in Cells [ Int J Mol Sci, 2023, 24(5)4720] PubMed: 36902164

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.