Home GPCR & G Protein Adrenergic Receptor agonist Xylometazoline HCl For research use only.

Xylometazoline HCl

Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM.

Xylometazoline HCl Chemical Structure

Xylometazoline HCl Chemical Structure

CAS No. 1218-35-5

Purity & Quality Control

Batch: S257601 Water]56 mg/mL]false]Ethanol]56 mg/mL]false]DMSO]27 mg/mL]false Purity: 99.71%
99.71

Xylometazoline HCl Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM.
Targets
adrenoceptor α1A [1] adrenoceptor α2C [1] adrenoceptor α1D [1] adrenoceptor α1B [1] adrenoceptor α2A [1] Click to View More Targets
80 nM 220 nM 450 nM 560 nM 980 nM
In vitro
In vitro Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline binds at adrenoceptor subtypeα1A, α1B, α1D, α2A, α2B, α2C with IC50 of 0.08, 0.56, 0.45, 0.98, 1.8, 0.22μM, repectively. [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00452270 Completed
Common Cold
Novartis
 March 2007 Phase 3

Chemical Information & Solubility

Molecular Weight 280.84 Formula

C16H24N2.HCl
CAS No. 1218-35-5 SDF Download Xylometazoline HCl SDF Download Xylometazoline HCl SDF
Smiles CC1=CC(=CC(=C1CC2=NCCN2)C)C(C)(C)C.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 56 mg/mL

Ethanol : 56 mg/mL

DMSO : 27 mg/mL ( (96.14 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Xylometazoline HCl | Xylometazoline HCl ic50 | Xylometazoline HCl price | Xylometazoline HCl cost | Xylometazoline HCl solubility dmso | Xylometazoline HCl purchase | Xylometazoline HCl manufacturer | Xylometazoline HCl research buy | Xylometazoline HCl order | Xylometazoline HCl mouse | Xylometazoline HCl chemical structure | Xylometazoline HCl mw | Xylometazoline HCl molecular weight | Xylometazoline HCl datasheet | Xylometazoline HCl supplier | Xylometazoline HCl in vitro | Xylometazoline HCl cell line | Xylometazoline HCl concentration | Xylometazoline HCl nmr