Home Metabolism P450 (e.g. CYP17) inhibitor - Xanthine Oxidase inhibitor Topiroxostat For research use only.

Topiroxostat

Topiroxostat is a xanthine oxidoreductase (XOR) inhibitor and used for treatment of gout and hyperuricemia. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment.

Topiroxostat Chemical Structure

Topiroxostat Chemical Structure

CAS No. 577778-58-6

Purity & Quality Control

Batch: S371901 DMSO]40 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.67%
99.67

Topiroxostat Related Products

Signaling Pathway

P450 (e.g. CYP17) Signaling Pathways

P450 (e.g. CYP17) Signaling Pathway

Biological Activity

Description Topiroxostat is a xanthine oxidoreductase (XOR) inhibitor and used for treatment of gout and hyperuricemia. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment.
Targets
XOR [1]
In vitro
In vitro Topiroxostat shows both structure- and mechanism-based inhibition of XOR[1].
In Vivo
In vivo Topiroxostat showed to suppress urinary albumin excretion dose-dependently and to inhibit the plasma XOR activity potently in diabetic nephropathy model. Therefore, it is possible that topiroxostat could protect or ameliorate microvascular injury and diabetic complications including DN in which ROS is involved as a pathogenetic factor[1].
Animal Research Animal Models Db/db mice
Dosages 0.1, 0.3, 1, and 3 mg/kg/day
Administration oral

Chemical Information & Solubility

Molecular Weight 248.24 Formula

C13H8N6
CAS No. 577778-58-6 SDF Download Topiroxostat SDF
Smiles C1=CN=CC=C1C2=NC(=NN2)C3=CC(=NC=C3)C#N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 40 mg/mL ( (161.13 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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