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Technical Data
| Formula | C13H8N6 |
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| Molecular Weight | 248.24 | CAS No. | 577778-58-6 | |
| Solubility (25°C)* | In vitro | DMSO | 40 mg/mL (161.13 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Topiroxostat is a xanthine oxidoreductase (XOR) inhibitor and used for treatment of gout and hyperuricemia. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment. | |
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| Targets |
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| In vitro | Topiroxostat shows both structure- and mechanism-based inhibition of XOR[1]. | |
| In vivo | Topiroxostat showed to suppress urinary albumin excretion dose-dependently and to inhibit the plasma XOR activity potently in diabetic nephropathy model. Therefore, it is possible that topiroxostat could protect or ameliorate microvascular injury and diabetic complications including DN in which ROS is involved as a pathogenetic factor[1]. |
Protocol (from reference)
| Animal Study:[1] |
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RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.