Home Epigenetics HDAC inhibitor SR-4370 For research use only.

SR-4370

SR-4370 is a potent and selective inhibitor of class I HDACs with IC50 of 0.13 µM, 0.58 µM, 0.006 µM, 2.3 µM, 3.7 µM for HDAC 1, HDAC 2, HDAC 3, HDAC 8, HDAC 6, respectively.SR-4370 suppresses AR signaling and in vivo prostate tumor growth.

SR-4370 Chemical Structure

SR-4370 Chemical Structure

CAS No. 1816294-67-3

Purity & Quality Control

SR-4370 Related Products

Signaling Pathway

HDAC Signaling Pathways

HDAC Signaling Pathway

Biological Activity

Description SR-4370 is a potent and selective inhibitor of class I HDACs with IC50 of 0.13 µM, 0.58 µM, 0.006 µM, 2.3 µM, 3.7 µM for HDAC 1, HDAC 2, HDAC 3, HDAC 8, HDAC 6, respectively.SR-4370 suppresses AR signaling and in vivo prostate tumor growth.
Targets
HDAC3 [1]
(Cell-free assay)		 HDAC1 [1]
(Cell-free assay)		 HDAC2 [1]
(Cell-free assay)		 HDAC8 [1]
(Cell-free assay)		 HDAC6 [1]
(Cell-free assay)
0.006 μM 0.13 μM 0.58 μM 2.3 μM 3.7 μM
In vitro
In vitro

SR-4370 can induce cell death of the aggressive breast cancer MDAMB-231 cells with IC50 of 12.6 μM.[1].

Chemical Information & Solubility

Molecular Weight 304.33 Formula

C17H18F2N2O

 
CAS No. 1816294-67-3 SDF --
Smiles CCCCNNC(=O)C1=CC=C(C=C1)C2=C(C(=CC=C2)F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 61 mg/mL ( (200.44 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 61 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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