Home DNA Damage/DNA Repair HDAC inhibitor - ACE inhibitor Sinapinic Acid For research use only.

Sinapinic Acid

Synonyms: Sinapic acid

Sinapinic acid (Sinapic acid) is a small naturally occurring hydroxycinnamic acid which belongs to phenylpropanoid family and commonly used as matrix in MALDI mass spectrometry. Sinapinic acid (Sinapic acid) acts as an inhibitor of HDAC, with IC50 of 2.27 mM, and also inhibits ACE-I activity.

Sinapinic Acid Chemical Structure

Sinapinic Acid Chemical Structure

CAS No. 530-59-6

Purity & Quality Control

Batch: S398101 DMSO]44 mg/mL]false]Ethanol]44 mg/mL]false]Water]Insoluble]false Purity: 99.9%
99.9

Sinapinic Acid Related Products

Signaling Pathway

HDAC Signaling Pathways

HDAC Signaling Pathway

Biological Activity

Description Sinapinic acid (Sinapic acid) is a small naturally occurring hydroxycinnamic acid which belongs to phenylpropanoid family and commonly used as matrix in MALDI mass spectrometry. Sinapinic acid (Sinapic acid) acts as an inhibitor of HDAC, with IC50 of 2.27 mM, and also inhibits ACE-I activity.
Targets
HDAC [3] ACE1 [4]
In vitro
In vitro

Sinapic acid is widespread in the plant kingdom (fruits, vegetables, cereal grains, oilseed crops, and some spices and medicinal plants). Sinapic acid shows antioxidant, antimicrobial, anti-inflammatory, anticancer, and anti-anxiety activity. Sinapic acid inhibits nuclear factor-kappa B (NF-κB) activation in macrophages. Via NF-κB inactivation sinapic acid suppresses the expression of proinflammatory mediators such as inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-α, and interleukin-1β. Sinapic acid exerts an inhibitory effect against tumorigenic colon cells, but a low influence on breast cancer cells. It also shows antiproliferative action (ability to prevent, or retard, the spread of malignant cells into surrounding tissue) on the human breast cancer T47D cell line[1].
In Vivo
In vivo

Sinapic acid is an important anxiolytic (anti-anxiety) agent. Its anxiolytic-like effect is mediated by the γ-aminobutyric acid (GABA) neurotransmitter system. Sinapic acid might act like the agonist of a specific GABA receptor. Due to its metal-chelating ability, it has a protective effect against arsenic-induced toxicity in rats as measured by the activities of serum hepatospecific enzymes, together with lipid peroxidative markers[1]. SA inhibits lipopolysaccharide-induced NO, prostaglandin E2, tumor necrosis factor-α and interleukin-1β production in a dose-dependent manner through the suppression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2, and proinflammatory cytokines expressions. In addition, SA exhibits cognitive-ameliorating effects in a CO2- or scopolamine-induced mouse amnesic model. It attenuates Aβ1-42 protein-induced hippocampal neuronal cell death and thus exhibits neuroprotection against Aβ protein-induced neuronal injuries[2].
Animal Research Animal Models Mouse model of amyloid β (Aβ)1-42 protein-induced Alzheimer
Dosages 10 mg/kg/day
Administration p.o.

Chemical Information & Solubility

Molecular Weight 224.21 Formula

C11H12O5
 
CAS No. 530-59-6 SDF Download Sinapinic Acid SDF
Smiles COC1=CC(=CC(=C1O)OC)C=CC(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 44 mg/mL ( (196.24 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 44 mg/mL

Water : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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