Home Transmembrane Transporters Calcium Channel inhibitor - Sodium Channel inhibitor - ERK inhibitor - p38 MAPK inhibitor - ROS inhibitor - NCX inhibitor SEA0400 For research use only.

SEA0400

SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner.

SEA0400 Chemical Structure

SEA0400 Chemical Structure

CAS No. 223104-29-8

Purity & Quality Control

Batch: S692001 DMSO]74 mg/mL]false]Ethanol]74 mg/mL]false]Water]Insoluble]false Purity: 99.96%
99.96

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Signaling Pathway

Calcium Channel Signaling Pathways

Calcium Channel Signaling Pathway

Biological Activity

Description SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner.
Targets
p38 MAPK [2] ERK [2] ROS [2] NCX [1]
(in cultured astrocytes)		 NCX [1]
(in cultured microglia)		 Click to View More Targets
5.0 nM 8.3 nM

Chemical Information & Solubility

Molecular Weight 371.38 Formula

C21H19F2NO3
CAS No. 223104-29-8 SDF --
Smiles CCOC1=CC=C(OC2=CC=C(OCC3=C(F)C=CC(=C3)F)C=C2)C(=C1)N
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 74 mg/mL ( (199.25 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 74 mg/mL

Water : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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