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RGX-202
RGX-202 is an SLC6A8 transporter inhibitor which suppress the colon cancer tumor. In addition to significantly reducing intracellular phosphocreatine and ATP levels and inducing tumour apoptosis, RGX-202 also inhibits creatine import both in vitro and in vivo.
RGX-202 Chemical Structure
CAS No. 353-09-3
Purity & Quality Control
Batch:
E122301
Water]26 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false
Purity:
99%
99
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Biological Activity
| Description | RGX-202 is an SLC6A8 transporter inhibitor which suppress the colon cancer tumor. In addition to significantly reducing intracellular phosphocreatine and ATP levels and inducing tumour apoptosis, RGX-202 also inhibits creatine import both in vitro and in vivo. |
|---|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT03597581 | Recruiting | Gastrointestinal Cancer|Gastrointestinal Neoplasms|Colorectal Cancer|Colorectal Neoplasms|Colorectal Carcinoma|Gastric Cancer|Gastric Neoplasm|KRAS Mutation-Related Tumors|CRC|Colorectal Cancer Metastatic |
Inspirna Inc. |
June 5 2018 | Phase 1 |
Chemical Information & Solubility
| Molecular Weight | 131.13 | Formula | C4H9N3O2 |
| CAS No. | 353-09-3 | SDF | -- |
| Smiles | NC(=N)NCCC(O)=O | ||
| Storage (From the date of receipt) | 3 years -20°C powder | ||
|
In vitro |
Water : 26 mg/mL DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Ethanol : Insoluble |
Molecular Weight Calculator |
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In vivo Add solvents to the product individually and in order. |
In vivo Formulation Calculator |
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Preparing Stock Solutions
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In vivo Formulation Calculator (Clear solution)
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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