Home Transmembrane Transporters Calcium Channel inhibitor Levamlodipine For research use only.

Levamlodipine

Synonyms: S-amlodipine

Levamlodipine (S-amlodipine) is a pharmacologically active enantiomer of amlodipine which belongs to the dihydropyridine group of calcium channel blocker. It acts on the L-type of calcium channels and its treatment results in vasodilation and a fall in blood pressure.

Levamlodipine Chemical Structure

Levamlodipine Chemical Structure

CAS No. 103129-82-4

Purity & Quality Control

Levamlodipine Related Products

Signaling Pathway

Calcium Channel Signaling Pathways

Calcium Channel Signaling Pathway

Biological Activity

Description Levamlodipine (S-amlodipine) is a pharmacologically active enantiomer of amlodipine which belongs to the dihydropyridine group of calcium channel blocker. It acts on the L-type of calcium channels and its treatment results in vasodilation and a fall in blood pressure.
Targets
calcium channel [1]
In vitro
In vitro Amlodipine is a calcium channel blocker prescribed for the management of angina and hypertension. As a racemic mixture, amlodipine contains (R)- and (S)-amlodipine isomers, but only (S)-amlodipine as the active moiety possesses therapeutic activity[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02358824 Completed
Hypertension
Chong Kun Dang Pharmaceutical
 February 2015 Phase 1
NCT02250833 Completed
Hypertension
Chong Kun Dang Pharmaceutical
 September 2014 Phase 1
NCT01844570 Unknown status
Primary Hypertension
Peking University First Hospital|Ministry of Science and Technology of the People´s Republic of China|Southern Medical University China|CSPC Ouyi Pharmaceutical Co. Ltd.
 February 2013 --

Chemical Information & Solubility

Molecular Weight 408.88 Formula

C20H25ClN2O5
CAS No. 103129-82-4 SDF Download Levamlodipine SDF
Smiles CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 82 mg/mL ( (200.54 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 82 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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