Home Epigenetics HDAC inhibitor KA2507 For research use only.

KA2507

KA2507, a potent, orally active and selective HDAC6 inhibitor with IC50 of 2.5 nM, shows antitumor activities and immune modulatory effects in preclinical models.

KA2507 Chemical Structure

KA2507 Chemical Structure

CAS No. 1636894-46-6

Purity & Quality Control

Batch: S993401 DMSO]64 mg/mL]false]Ethanol]64 mg/mL]false]Water]Insoluble]false Purity: 98.59%
98.59

KA2507 Related Products

Signaling Pathway

HDAC Signaling Pathways

HDAC Signaling Pathway

Biological Activity

Description KA2507, a potent, orally active and selective HDAC6 inhibitor with IC50 of 2.5 nM, shows antitumor activities and immune modulatory effects in preclinical models.
Targets
HDAC6 [1]
(in HDAC biochemical and cellular target engagement assays)
2.5 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04186156 Withdrawn
Biliary Tract Cancer
Karus Therapeutics Limited|University College London
 March 5 2020 Phase 2
NCT03008018 Completed
Solid Tumor Adult
Karus Therapeutics Limited
 August 7 2017 Phase 1

Chemical Information & Solubility

Molecular Weight 322.32 Formula

C16H14N6O2
CAS No. 1636894-46-6 SDF --
Smiles ONC(=O)C1=CC=C(CN(C2=NC=CN=C2)C3=NC=CN=C3)C=C1
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 64 mg/mL ( (198.56 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 64 mg/mL

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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