Home JAK/STAT STAT inhibitor - Immunology & Inflammation related inhibitor GYY4137 For research use only.

GYY4137

GYY4137 is a novel, water-soluble hydrogen sulfide (H2S)–releasing molecule with vasodilator and antihypertensive activity. GYY4137 shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. GYY4137 also shows anti-inflammatory activity.

GYY4137 Chemical Structure

GYY4137 Chemical Structure

CAS No. 106740-09-4

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GYY4137 Related Products

Signaling Pathway

STAT Signaling Pathways

STAT Signaling Pathway

Biological Activity

Description GYY4137 is a novel, water-soluble hydrogen sulfide (H2S)–releasing molecule with vasodilator and antihypertensive activity. GYY4137 shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. GYY4137 also shows anti-inflammatory activity.
Targets
STAT3 [2]
In vitro
In vitro

GYY4137 (400-800 µM) causes concentration-dependent killing of seven different human cancer cell lines (HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS) but does not affect survival of normal human lung fibroblasts (IMR90, WI-38).[4]
Cell Research Cell lines HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS
Concentrations 400 µM, 800 µM
Incubation Time 5 days, 8 days
Method

Live cell incubated with GYY4137(400 or 800 µM) are collected after 5 days and counted in triplicate after staining with trypan blue using a haemocytometer for cell viability assay. The generation of H2S from GYY4137(400 µM) is determined in aliquots (100 µl) withdrawn at timed intervals (up to 7 days) from cultured MCF-7 cells maintained in Dulbecco's modified Eagle's medium.
In Vivo
In vivo

In the complete Freund's adjuvant (CFA)-treated mouse, GYY4137 injected 1 hr prior to CFA increased knee joint swelling while an anti-inflammatory effect, as demonstrated by reduced synovial fluid myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAG) activity and decreased TNF-α, IL-1β, IL-6 and IL-8 concentration, is apparent when GYY4137 was injected 6 hrs after CFA.[3]
Animal Research Animal Models Complete Freund
Dosages 50 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 376.47 Formula

C11H16NO2PS2.C4H9NO
CAS No. 106740-09-4 SDF --
Smiles COC1=CC=C(C=C1)[P](S)(=S)N2CCOCC2.C3COCCN3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 75 mg/mL ( (199.21 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 25 mg/mL

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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