Home JAK/STAT STAT inhibitor APTSTAT3-9R For research use only.

APTSTAT3-9R

APTSTAT3-9R is a specific STAT3-binding peptide with addition of a cell-penetrating motif. The treatment of APTSTAT3-9R in various types of cancer cells blocks STAT3 phosphorylation and reduces expression of STAT targets.

APTSTAT3-9R Chemical Structure

APTSTAT3-9R Chemical Structure

CAS No. no CAS

Purity & Quality Control

APTSTAT3-9R Related Products

Signaling Pathway

STAT Signaling Pathways

STAT Signaling Pathway

Biological Activity

Description APTSTAT3-9R is a specific STAT3-binding peptide with addition of a cell-penetrating motif. The treatment of APTSTAT3-9R in various types of cancer cells blocks STAT3 phosphorylation and reduces expression of STAT targets.
Targets
STAT3 [1]
(In A549 cells)
In vitro
In vitro APTSTAT3-9R effectively inhibited phosphorylation of STAT3 but did not affect the level of AKT phosphorylation and it suppresses cell viability and proliferation of cancer cells[1].
Cell Research Cell lines A549 cells
Concentrations 0-100 μmol/L
Incubation Time 12 h
Method Cells are plated in a 96-well plate (5,000 cells/well) and incubated for 12 hours. After incubation the cells are treated with nine-arginine (9R), APTSTAT3-9R, and APRscr-9R for 12 hours. After 12 hours incubation, 20 μL MTT (5 mg/mL) is added to each well. After 4 hours, 100 μL dimethyl sulfoxide is added to each well, and absorbance is measured at 570 nm using a Spectra Macplus microplate reader
In Vivo
In vivo APTSTAT3-9R could effectively suppress tumor growth in the in vivo allograft and xenograft tumor models by inhibiting STAT3 phosphorylation[1].
Animal Research Animal Models Human lung carcinoma xenograft model(by subcutaneous implantation of A549 cancer cells into female BALB/c nude mice)
Dosages 8 mg/kg
Administration intratumoral injection

Chemical Information & Solubility

Molecular Weight 4947.51 Formula

C223H330N80O51
CAS No. no CAS SDF Download APTSTAT3-9R SDF
Smiles CC(C)CC(NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CCC(N)=O)NC(=O)C(CC2=CC=C(O)C=C2)NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=C[NH]C4=CC=CC=C34)NC(=O)C(NC(=O)C(CC5=C[NH]C6=CC=CC=C56)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CC7=C[NH]C8=CC=CC=C78)NC(=O)C(NC(=O)C(CC9=C[NH]C%10=CC=CC=C9%10)NC(=O)C(CO)NC(=O)CNC(=O)C%11CCCN%11C(=O)C(CC%12=C[NH]C%13=CC=CC=C%12%13)NC(=O)C(CCC(N)=O)NC(=O)C(CC%14=CC=CC=C%14)NC(=O)CNC(=O)C(N)CC%15=C[NH]C=N%15)C(C)O)C(C)O)C(=O)NC(CCCCN)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NC(CO)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(O)=O
Storage (From the date of receipt)

In vitro
Batch:

Water : 100 mg/mL


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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