Home JAK/STAT STAT inhibitor STAT3-IN-1 For research use only.

STAT3-IN-1

STAT3-IN-1 (compound 7d) is an excellent, selective and orally active inhibitor of STAT3 with IC50 of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 induces apoptosis of tumor cells.

STAT3-IN-1 Chemical Structure

STAT3-IN-1 Chemical Structure

CAS No. 2059952-75-7

Purity & Quality Control

STAT3-IN-1 Related Products

Signaling Pathway

STAT Signaling Pathways

STAT Signaling Pathway

Biological Activity

Description STAT3-IN-1 (compound 7d) is an excellent, selective and orally active inhibitor of STAT3 with IC50 of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 induces apoptosis of tumor cells.
Targets
STAT3 [1]
(in HT29 cells)		 STAT3 [1]
(in MDA-MB 231 cells)
1.82 μM 2.14 μM

Chemical Information & Solubility

Molecular Weight 475.53 Formula

C28H29NO6
CAS No. 2059952-75-7 SDF --
Smiles COC1=CC(=CC(=C1)OC)\C=C\C2=CC=C(NC(=O)\C=C\C3=CC(=C(OC)C(=C3)OC)OC)C=C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 32 mg/mL ( (67.29 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 14 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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