Fresolimumab (Anti-TGFb1)

Synonyms: GC1008

Catalog No.A2336 Purity:99%

Fresolimumab (Anti-TGFb1) is a pan-specific, recombinant, fully human monoclonal antibody directed against human transforming growth factor (TGF) beta 1, 2, and 3 with potential antineoplastic activity. MW : 145.5 KD.

Purity & Quality Control

Batch: Purity: 99% Protein concentration: 3.85mg/ml Endotoxin Level: ＜1EU/mg

Choose Selective TGF-beta/Smad Inhibitors

Name	Citation	ALK1	ALK2	ALK3	ALK4	TGFβRI/ALK5	ALK6	TGFβRII	TGF-β	ALK7	Others
SB431542	707					+
LDN-193189	241	++++	++++	+++			+++
Galunisertib (LY2157299)	183					+
LY2109761	130					++		+
SB525334	110					+++
SB505124	34				+	++
GW788388	24					++
LY364947	49					+		+			RIPK2,CK1δ,MLK-7K
RepSox (E-616452)	69					+++
LDN-193189 2HCl	95	++++	++++	+++			+++
K02288	24	++++	++++	++			+++
TGFβRI-IN-3	2					++++
R-268712	0					++++
BIBF-0775	0					++
TP0427736 HCl	6					+++
A-83-01	44				++	+++				+++
LDN-214117	4		++
SD-208	21					++
Vactosertib (TEW-7197)	24				+++	+++
ML347	5	++	++
LDN-212854	7	++++	++++	+	+	+
DMH1	49		+
Dorsomorphin 2HCl		✔								AMPK
PF-06952229					✔
Ginsenoside Rh4								✔
SIS3									✔
AUDA								✔		TNF-α,IL-1β,MMP-9
PD 169316								✔		Activin A,Enterovirus71,p38 MAPK
TA-02							✔			p38 MAPK
ITD-1								✔
LY 3200882					✔
Alantolactone									✔	STAT3
Halofuginone									✔	prolyl-tRNA synthetase
SIS3 HCl									✔
Dorsomorphin		✔								AMPK
Hesperetin								✔		Histamine receptor

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Fresolimumab (Anti-TGFb1) is a pan-specific, recombinant, fully human monoclonal antibody directed against human transforming growth factor (TGF) beta 1, 2, and 3 with potential antineoplastic activity. MW : 145.5 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	948564-73-6
Molecular Weight	145.5 kDa
Isotype	Human IgG4SP
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100mMPro-Ac,20mMArg-Ac，pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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