Home Proteases Serine Protease inhibitor - COVID-19 inhibitor FOY251 For research use only.

FOY251

FOY251, an active metabolite of camostat mesilate, is an inhibitor of synthetic serine protease. FOY251 inhibits SARS-CoV-2 infection.

FOY251 Chemical Structure

FOY251 Chemical Structure

CAS No. 71079-09-9

Purity & Quality Control

Batch: S351101 DMSO]82 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.00%
99.00

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Biological Activity

Description FOY251, an active metabolite of camostat mesilate, is an inhibitor of synthetic serine protease. FOY251 inhibits SARS-CoV-2 infection.
Targets
synthetic serine protease [1]
In vitro
In vitro

FOY-251 decreases equivalent current (Ieq) in M-1 cells in a dose-dependent manner and inhibits the protease activity of prostasin in vitro.[1]
Cell Research Cell lines Mouse cortical collecting duct cell line (M-1 cells)
Concentrations 0.01–10 μM
Incubation Time 24 h
Method

M-1 cells were cultured on semi-permeable membrane, serum deprived for 24 h, and treated with 0.01-1 μM camostat mesilate or 0.01-10 μM FOY-251 from the apical side. After 24 h incubation, transepithelial voltage (Vte) and resistance (Rte) were measured with a volt ohm meter. Ieq was determined as the ratio of Vte to Rte and was normalized by dividing Ieq by the surface area (113 mm2 ) of active membrane.
In Vivo
In vivo

FOY-251 increases the circulating levels of FGF21 of transcription and plasma are maintained with induction of liver integrated stress response (ISR) transcription target genes up to 1 wk of treatment in both ob/ob and lean mice, also increases plasma FGF21 levels when dosed to DIO mice.[3]
Animal Research Animal Models Male ob/ob mice, lean and diet-induced obese (DIO) C57BL/6 mice
Dosages 0.8 mg/g food
Administration p.o.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04451083 Completed
Healthy Volunteers
Ono Pharmaceutical Co. Ltd
 July 1 2020 Phase 1
NCT02693093 Completed
Chronic Pancreatitis
Kangen Pharmaceuticals Inc
 February 24 2016 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 409.41 Formula

C17H19N3O7S
CAS No. 71079-09-9 SDF --
Smiles C[S](O)(=O)=O.NC(=N)NC1=CC=C(C=C1)C(=O)OC2=CC=C(CC(O)=O)C=C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 82 mg/mL ( (200.28 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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