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Serine Protease

Serine Protease Products

All (16)
Serine Protease Inhibitors (16)
New Serine Protease Products

Catalog No.	Product Name	Information	Product Use Citations
S7380	Leupeptin Hemisulfate	Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.	Nat Commun, 2023, 14(1):4066 Acta Pharm Sin B, 2022, 12(6):2869-2886 Theranostics, 2022, 12(14):6395-6408
S3025	PMSF	PMSF (Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride) is an irreversible serine/cysteine protease inhibitor.	Cell Death Discov, 2024, 10(1):171 Cell Biosci, 2023, 13(1):9 Cell Biosci, 2023, 13(1):9
S1811	Amiloride HCl	Amiloride HCl is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).	J Extracell Vesicles, 2024, 13(4):e12426 J Extracell Vesicles, 2024, 13(4):e12426 Virus Res, 2024, 339:199258
S1386	Nafamostat mesilate (FUT-175)	Nafamostat mesilate is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis. Nafamostat mesylate blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. Nafamostat Mesilate attenuates inflammation and apoptosis.	Cell Death Dis, 2024, 15(2):109 CNS Neurosci Ther, 2024, 30(6):e14822 Pathogens, 2023, 13(1)18
S8136	Sivelestat	Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other proteases.	Nat Commun, 2024, 15(1):6519 Cell Mol Gastroenterol Hepatol, 2022, S2352-345X(22)00097-2 Microb Pathog, 2022, 166:105558
S7378	AEBSF HCl	AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.	Acta Pharm Sin B, 2024, 14(6):2554-2566 Int J Med Sci, 2024, 21(7):1204-1212 Int J Biol Sci, 2023, 19(13):4327-4339
S4666	Sivelestat sodium tetrahydrate	Sivelestat sodium tetrahydrate (ONO5046-Na, EI546, LY544349) is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.	J Immunol, 2021, 206(4):797-806 Aging (Albany NY), 2020, 12(17):16820-16836 Front Microbiol, 2020, 10:2936
S2101	Gabexate Mesylate	Gabexate Mesylate(FOY) is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation.	Front Oncol, 2019, 0.87569444444 J Biol Chem, 2018, 293(34):13112-13124 Invest Ophthalmol Vis Sci, 2016, 57(14):6461-6473
S7218	Alvelestat (AZD9668)	Alvelestat (AZD9668, Avelestat) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and K_i of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2.	Proc Natl Acad Sci U S A, 2021, 118(34)e2102435118 Sci Rep, 2019, 9(1):715 Exp Cell Res, 2019, 382(2):111486
S8457	UK-371804 HCl	UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).	PNAS Nexus, 2022, 1(3):pgac104 Front Genet, 2021, 12:651882
S7377	Aprotinin	Aprotinin is a small protein serine protease inhibitor (Kd=0.06 pM for bovine β-trypsin), used to reduce perioperative blood loss and transfusion.	Elife, 2021, 10e65962 Autophagy, 2017, 13(3):538-553
S0042	Fulacimstat	Fulacimstat (BAY1142524) is an orally available inhibitor of chymase with IC50 of 4 nM and 3 nM for human and hamster chymase enzyme, respectively.
S3511	FOY251	FOY251, an active metabolite of camostat mesilate, is an inhibitor of synthetic serine protease. FOY251 inhibits SARS-CoV-2 infection.
E1342	Sebetralstat	Sebetralstat(KVD900) is a plasma kallikrien inhibitor.
E1014	Upamostat (WX-671)	Upamostat (WX-671), a novel serine protease urokinase (uPA) inhibitor by inhibiting the urokinase-type plasminogen activator (uPA) system.
S0479	ZK824859	ZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.
S7380	Leupeptin Hemisulfate	Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.	Nat Commun, 2023, 14(1):4066 Acta Pharm Sin B, 2022, 12(6):2869-2886 Theranostics, 2022, 12(14):6395-6408
S3025	PMSF	PMSF (Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride) is an irreversible serine/cysteine protease inhibitor.	Cell Death Discov, 2024, 10(1):171 Cell Biosci, 2023, 13(1):9 Cell Biosci, 2023, 13(1):9
S1811	Amiloride HCl	Amiloride HCl is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).	J Extracell Vesicles, 2024, 13(4):e12426 J Extracell Vesicles, 2024, 13(4):e12426 Virus Res, 2024, 339:199258
S1386	Nafamostat mesilate (FUT-175)	Nafamostat mesilate is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis. Nafamostat mesylate blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. Nafamostat Mesilate attenuates inflammation and apoptosis.	Cell Death Dis, 2024, 15(2):109 CNS Neurosci Ther, 2024, 30(6):e14822 Pathogens, 2023, 13(1)18
S8136	Sivelestat	Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other proteases.	Nat Commun, 2024, 15(1):6519 Cell Mol Gastroenterol Hepatol, 2022, S2352-345X(22)00097-2 Microb Pathog, 2022, 166:105558
S7378	AEBSF HCl	AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.	Acta Pharm Sin B, 2024, 14(6):2554-2566 Int J Med Sci, 2024, 21(7):1204-1212 Int J Biol Sci, 2023, 19(13):4327-4339
S4666	Sivelestat sodium tetrahydrate	Sivelestat sodium tetrahydrate (ONO5046-Na, EI546, LY544349) is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.	J Immunol, 2021, 206(4):797-806 Aging (Albany NY), 2020, 12(17):16820-16836 Front Microbiol, 2020, 10:2936
S2101	Gabexate Mesylate	Gabexate Mesylate(FOY) is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation.	Front Oncol, 2019, 0.87569444444 J Biol Chem, 2018, 293(34):13112-13124 Invest Ophthalmol Vis Sci, 2016, 57(14):6461-6473
S7218	Alvelestat (AZD9668)	Alvelestat (AZD9668, Avelestat) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and K_i of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2.	Proc Natl Acad Sci U S A, 2021, 118(34)e2102435118 Sci Rep, 2019, 9(1):715 Exp Cell Res, 2019, 382(2):111486
S8457	UK-371804 HCl	UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).	PNAS Nexus, 2022, 1(3):pgac104 Front Genet, 2021, 12:651882
S7377	Aprotinin	Aprotinin is a small protein serine protease inhibitor (Kd=0.06 pM for bovine β-trypsin), used to reduce perioperative blood loss and transfusion.	Elife, 2021, 10e65962 Autophagy, 2017, 13(3):538-553
S0042	Fulacimstat	Fulacimstat (BAY1142524) is an orally available inhibitor of chymase with IC50 of 4 nM and 3 nM for human and hamster chymase enzyme, respectively.
S3511	FOY251	FOY251, an active metabolite of camostat mesilate, is an inhibitor of synthetic serine protease. FOY251 inhibits SARS-CoV-2 infection.
E1342	Sebetralstat	Sebetralstat(KVD900) is a plasma kallikrien inhibitor.
E1014	Upamostat (WX-671)	Upamostat (WX-671), a novel serine protease urokinase (uPA) inhibitor by inhibiting the urokinase-type plasminogen activator (uPA) system.
S0479	ZK824859	ZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.

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