Home Proteases Serine Protease inhibitor AEBSF HCl For research use only.

AEBSF HCl

AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.

AEBSF HCl Chemical Structure

AEBSF HCl Chemical Structure

CAS No. 30827-99-7

Purity & Quality Control

AEBSF HCl Related Products

Biological Activity

Description AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.
Features Broad spectrum, irreversible serine protease inhibitor.
Targets
serine protease [1]
In vitro
In vitro AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. [1] AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. [2] AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern. [4]
In Vivo
In vivo AEBSF (76.8 mg/kg daily i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection. [3] AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model. [4]
Animal Research Animal Models Mice infected by a lethal T. Gondii
Dosages ~76.8 mg/kg daily
Administration i.p.

Chemical Information & Solubility

Molecular Weight 239.69 Formula

C8H11ClFNO2S
CAS No. 30827-99-7 SDF Download AEBSF HCl SDF
Smiles C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (417.2 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 50 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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