AEBSF HCl

Catalog No.S7378 Batch:S737825

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Technical Data

Formula

C8H11ClFNO2S
Molecular Weight 239.69 CAS No. 30827-99-7
Solubility (25°C)* In vitro DMSO 100 mg/mL (417.2 mM)
Water 100 mg/mL (417.2 mM)
Ethanol 50 mg/mL (208.6 mM)
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
5.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
Clear solution
5% DMSO 95% Corn oil
0.83mg/ml Taking the 1 mL working solution as an example, add 50 μL of 16.6 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.
Targets
serine protease [1]
In vitro AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. [1] AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. [2] AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern. [4]
In vivo AEBSF (76.8 mg/kg daily i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection. [3] AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model. [4]
Features Broad spectrum, irreversible serine protease inhibitor.

Protocol (from reference)

Animal Study:[3]
  • Animal Models

    Mice infected by a lethal T. Gondii

  • Dosages

    ~76.8 mg/kg daily

  • Administration

    i.p.

Selleck's AEBSF HCl has been cited by 14 publications

Pharmacokinetic enhancement of oncolytic virus M1 by inhibiting JAK‒STAT pathway [ Acta Pharm Sin B, 2024, 14(6):2554-2566] PubMed: 38828147
Targeting Cancer Mitochondria by Inducing an Abnormal Mitochondrial Unfolded Protein Response Leads to Tumor Suppression [ Int J Med Sci, 2024, 21(7):1204-1212] PubMed: 38818479
Sirtuin-3 activates the mitochondrial unfolded protein response and reduces cerebral ischemia/reperfusion injury [ Int J Biol Sci, 2023, 19(13):4327-4339] PubMed: 37705748
Sirtuin-3 activates the mitochondrial unfolded protein response and reduces cerebral ischemia/reperfusion injury [ Int J Biol Sci, 2023, 19(13):4327-4339] PubMed: 37705748
Inhibition of signal peptidase complex expression affects the development and survival of Schistosoma japonicum [ Front Cell Infect Microbiol, 2023, 13:1136056] PubMed: 36936776
Inhibition of signal peptidase complex expression affects the development and survival of Schistosoma japonicum [ Front Cell Infect Microbiol, 2023, 13:1136056] PubMed: 36936776
Alpha-1 Antitrypsin-Induced Endoplasmic Reticulum Stress Promotes Invasion by Extravillous Trophoblasts [ Int J Mol Sci, 2021, 22(7)3683] PubMed: 33916165
Evaluation of enzymatic proteoglycan loss and collagen degradation in human articular cartilage using ultrashort echo time-based biomarkers: A feasibility study [ NMR Biomed, 2021, e4664] PubMed: 34904305
Rescue of HSP70 in Spinal Neurons Alleviates Opioids-Induced Hyperalgesia via the Suppression of Endoplasmic Reticulum Stress in Rodents [ Front Cell Dev Biol, 2020, 8:269] PubMed: 32500072
Thapsigargin Promotes Colorectal Cancer Cell Migration Through Upregulation of lncRNA MALAT1 [ Oncol Rep, 2020, 43(4):1245-1255] PubMed: 32323831

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.