Home JAK/STAT STAT activator - Beta Amyloid inhibitor Colivelin For research use only.

Colivelin

Synonyms: CLN

Colivelin (CLN) is a brain-penetrant neuroprotective peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3.

Colivelin Chemical Structure

Colivelin Chemical Structure

CAS No. 867021-83-8

Purity & Quality Control

Batch: S966401 Water]100 mg/mL]false]]]false]]]false Purity: 99.62%
99.62

Colivelin Related Products

Signaling Pathway

STAT Signaling Pathways

STAT Signaling Pathway

Biological Activity

Description Colivelin (CLN) is a brain-penetrant neuroprotective peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3.
Targets
Aβ [1] STAT3 [1]
In vitro
In vitro

Colivelin, a brain penetrant neuroprotective peptide, significantly increases the p-STAT3 protein levels in BV-2 cells.[2]
Cell Research Cell lines BV-2 cells
Concentrations 50 µg/ml
Incubation Time 4 h
Method

BV-2 cells are maintained at 37℃ with 5% CO2. To build OGD models, BV-2 cells are washed with PBS for 3 times, and cultured in glucose-free DMEN and placed in a hypoxia incubation chamber filled with the gas mixture for 4 h at 37℃. The culture medium is then replaced by the normal medium containing 4.5 g/L glucose and cells are cultured under normoxic conditions for reoxygenation for 24 h. BV-2 cells are treated with 50 µg/ml rmMFG-E8 or/and Colivelin TFA, respectively. The expression changes of proteins (p-STAT3 and SOCS3) are analyzed by Western blot assay.
In Vivo
In vivo

Colivelin protects against ischemic brain injury and improves neurological outcomes, by elevating anti-apoptotic genes up-regulation and activates JAK/STAT3 signaling afetr ischemic stroke.[1]
Animal Research Animal Models Male C57BL/6 mice of middle cerebral artery occlusion (MCAO) models
Dosages 1 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04637282 Not yet recruiting
Juvenile Neuronal Ceroid Lipofuscinosis
Polaryx Therapeutics Inc.
 December 1 2024 Phase 3
NCT05879744 Active not recruiting
NHL|NHL Relapsed Adult
Cullinan Therapeutics Inc.
 May 31 2023 Phase 1
NCT05143996 Recruiting
Relapsed/Refractory Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS)
Cullinan Therapeutics Inc.
 November 18 2021 Phase 1
NCT04974307 Completed
CLN3-related Disorders|Low Vision
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC)
 September 30 2021 Not Applicable
NCT04480476 Withdrawn
Late-infantile Neuronal Ceroid Lipofuscinosis Type 2 (CLN2)
REGENXBIO Inc.
 March 31 2021 --
NCT04462692 Withdrawn
Neuronal Ceroid Lipofuscinosis Type 2 (CLN2)
REGENXBIO Inc.
 March 31 2021 --

Chemical Information & Solubility

Molecular Weight 2645.10 Formula

C119H206N32O35
CAS No. 867021-83-8 SDF --
Smiles CCC(C)C(C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(C(C)O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)C(C)NC(=O)CNC(=O)C(C)NC(=O)C2CCCN2C(=O)C(C)NC(=O)C3CCCN3C(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)N
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 100 mg/mL


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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