Home Neuronal Signaling Adrenergic Receptor agonist Adrenalone HCl For research use only.

Adrenalone HCl

Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.

Adrenalone HCl Chemical Structure

Adrenalone HCl Chemical Structure

CAS No. 62-13-5

Purity & Quality Control

Batch: S318502 DMSO]44 mg/mL]false]Water]44 mg/mL]false]Ethanol]Insoluble]false Purity: 99.99%
99.99

Adrenalone HCl Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.
Targets
α1-adrenergic receptor [1]
In vitro
In vitro Adrenalone (12 μM) inhibits conversion of dopamine to norepinephrine by inhibiting dopamine β oxidase. The structure of Adrenalone differs from epinine only in that the former possesses a ketone group in the β position. [1] The reduction of adrenalone (0.1 mM) by hydrated electrons in nitrogenated aqueous solutions containing either 10 or 100 mM tert-butyl alcohol results in identical transient spectra, therefore all OH radicals have been scavenged. While adrenalone behaves like a carbonyl compound during reduction, oxidation reactions are primarily governed by the catechol functional group. [2] Adrenalone, which is a topical nasal decongestant, hemostatic, and vasoconstrictor, is a keton form of the natural substrate epinephrine. Adrenalone contains an aromatic ring that forms hydrophobic interactions with Phe72, Tyr152, and Phe317, an amine group that forms an ionic bond with Asp75, and a hydroxyl group that forms a hydrogen bond with Ala145. Adrenalone at 10 μM (100 μM) reduces substrate uptake to 99% (27%). [3]
In Vivo
In vivo Adrenalone (0.05%) administrated topically to the eyes of rabbits at 30 min intervals results in concentration of 7.75 mg/kg, 0.87 mg/kg and 2.51 mg/kg in cornea, aqueous humor and iris-ciliary body, respectively. [4]

Chemical Information & Solubility

Molecular Weight 217.65 Formula

C9H11NO3.HCl
CAS No. 62-13-5 SDF Download Adrenalone HCl SDF
Smiles CNCC(=O)C1=CC(=C(C=C1)O)O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 44 mg/mL ( (202.15 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 44 mg/mL

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Adrenalone HCl | Adrenalone HCl ic50 | Adrenalone HCl price | Adrenalone HCl cost | Adrenalone HCl solubility dmso | Adrenalone HCl purchase | Adrenalone HCl manufacturer | Adrenalone HCl research buy | Adrenalone HCl order | Adrenalone HCl mouse | Adrenalone HCl chemical structure | Adrenalone HCl mw | Adrenalone HCl molecular weight | Adrenalone HCl datasheet | Adrenalone HCl supplier | Adrenalone HCl in vitro | Adrenalone HCl cell line | Adrenalone HCl concentration | Adrenalone HCl nmr