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Technical Data
| Formula | C9H11NO3.HCl |
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| Molecular Weight | 217.65 | CAS No. | 62-13-5 | |
| Solubility (25°C)* | In vitro | DMSO | 44 mg/mL (202.15 mM) | |
| Water | 44 mg/mL (202.15 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors. | |
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| Targets |
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| In vitro | Adrenalone (12 μM) inhibits conversion of dopamine to norepinephrine by inhibiting dopamine β oxidase. The structure of Adrenalone differs from epinine only in that the former possesses a ketone group in the β position. [1] The reduction of adrenalone (0.1 mM) by hydrated electrons in nitrogenated aqueous solutions containing either 10 or 100 mM tert-butyl alcohol results in identical transient spectra, therefore all OH radicals have been scavenged. While adrenalone behaves like a carbonyl compound during reduction, oxidation reactions are primarily governed by the catechol functional group. [2] Adrenalone, which is a topical nasal decongestant, hemostatic, and vasoconstrictor, is a keton form of the natural substrate epinephrine. Adrenalone contains an aromatic ring that forms hydrophobic interactions with Phe72, Tyr152, and Phe317, an amine group that forms an ionic bond with Asp75, and a hydroxyl group that forms a hydrogen bond with Ala145. Adrenalone at 10 μM (100 μM) reduces substrate uptake to 99% (27%). [3] | |
| In vivo | Adrenalone (0.05%) administrated topically to the eyes of rabbits at 30 min intervals results in concentration of 7.75 mg/kg, 0.87 mg/kg and 2.51 mg/kg in cornea, aqueous humor and iris-ciliary body, respectively. [4] |
Protocol (from reference)
References
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.