Home Transmembrane Transporters Calcium Channel inhibitor Tetrandrine For research use only.

Tetrandrine

Synonyms: NSC-77037, Fanchinine, d-Tetrandrine

Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.

Tetrandrine Chemical Structure

Tetrandrine Chemical Structure

CAS No. 518-34-3

Purity & Quality Control

Tetrandrine Related Products

Signaling Pathway

Calcium Channel Signaling Pathways

Calcium Channel Signaling Pathway

Biological Activity

Description Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.
Targets
Calcium channel [1]
In vitro
In vitro

Tetrandrine inhibits voltage-gated Ca2+ currents with an IC50 of 10.1 mM in isolated nerve terminals of the rat neurohypophysis. Tetrandrine is a high-affinity blocker of the type II, maxi-Ca(2+)-activated K+ channel of the rat neurohypophysial terminals with an IC50 of 0.21 mM. [1] Another study shows that Tetrandrine also inhibits Ca(2+)-activated Cl- currents (I(Cl,Ca)) with an IC50 of 5.2 mM. [2] Tetrandrine inhibits the proliferation of human leukemic HL-60 cells via induction of apoptosis. [3]
Experimental Result Images Methods Biomarkers Images PMID
Western blot p-GSK3β / GSK3β / p-β-catenin / β-catenin Atg7 p-ASK1 / ASK1 / p-SEK1 / SEK1 / p-JNK1/2 / JNK1/2 29334999
Growth inhibition assay Cell viability 29285984
Immunofluorescence E-cadherin / Vimentin p-STAT3 29334999

Chemical Information & Solubility

Molecular Weight 622.75 Formula

C38H42N2O6
CAS No. 518-34-3 SDF Download Tetrandrine SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 12 mg/mL ( (19.26 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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