Home Transmembrane Transporters Calcium Channel inhibitor - Autophagy activator Nimodipine For research use only.

Nimodipine

Synonyms: BAY E 9736

Nimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.

Nimodipine Chemical Structure

Nimodipine Chemical Structure

CAS No. 66085-59-4

Purity & Quality Control

Nimodipine Related Products

Signaling Pathway

Calcium Channel Signaling Pathways

Calcium Channel Signaling Pathway

Biological Activity

Description Nimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.
Targets
Calcium channel [1]
In vitro
In vitro Nimodipine decreases both the peak amplitude and the integrated area of the AHP in an age- and concentration-dependent manner. Nimodipine (100 nM) significantly reduces the AHP in aging CA1 neurons. Nimodipine increases excitability in an age- and concentration-dependent manner by decreasing spike frequency accommodation (increasing the number of action potentials during prolonged depolarizing current injection). Nimodipine decreases accommodation only at higher concentrations in young CA1 neurons. [1] Nimodipine decreases the plateau phase of the calcium AP at concentrations as low as 100 nM in aging neurons and 10 mM in young rat neurons. [2]
In Vivo
In vivo Nimodipine results in reversible, dose-related suppression of the compound action potential of the auditory nerve (CAP; N1-P1), a prolongation of N1 latency at suprathreshold levels, an elevated CAP threshold, a decrease in N1 latency at a constant amplitude measured at CAP threshold, a reduction in cochlear microphonics (CM), and a reduction of the negative summating potential (SP) to a point where it becomes positive. [3] Nimodipine (10 mg/kg, SC), an L-type dihydropyridine Ca2+ channel antagonist, appears to completely block the establishment of conditioning of cocaine's effects, but only partially blocks sensitization to cocaine. [4] Nimodipine (5-20 mg/kg, SC) inhibits in a dose-related manner self-administration both of cocaine and morphine contingent upon a nose-poke response. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05995405 Recruiting
Aneurysmal Subarachnoid Hemorrhage (aSAH)
Acasti Pharma Inc.
 October 20 2023 Phase 3
NCT04998370 Recruiting
Subarachnoid Hemorrhage Aneurysmal|Vasospasm|Delayed Cerebral Ischemia|Delayed Ischemic Neurological Deficit
University of Zurich
 August 18 2021 --
NCT04649398 Recruiting
Subarachnoid Hemorrhage Aneurysmal|Delayed Cerebral Ischemia|Vasospasm Cerebral
Medical University of Vienna|University of Vienna|Austrian Science Fund (FWF)
 November 25 2020 --
NCT02991157 Completed
Subarachnoid Hemorrhage Aneurysmal
National Institute of Mental Health and Neuro Sciences India
 December 2016 --
NCT01835665 Completed
Progranulin Mutation Carriers
University of California San Francisco|The Bluefield Project to Cure Frontotemporal Dementia
 March 2013 Phase 1
NCT01551368 Terminated
Infertility
Mount Sinai Hospital Canada
 December 2012 Phase 2

Chemical Information & Solubility

Molecular Weight 418.44 Formula

C21H26N2O7
CAS No. 66085-59-4 SDF Download Nimodipine SDF
Smiles CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 84 mg/mL ( (200.74 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 84 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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