Home Transmembrane Transporters Calcium Channel inhibitor Nifedipine For research use only.

Nifedipine

Synonyms: BAY-a-1040

Nifedipine is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.

Nifedipine Chemical Structure

Nifedipine Chemical Structure

CAS No. 21829-25-4

Purity & Quality Control

Nifedipine Related Products

Signaling Pathway

Calcium Channel Signaling Pathways

Calcium Channel Signaling Pathway

Biological Activity

Description Nifedipine is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.
Targets
calcium channel [1]
In vitro
In vitro Nifedipine causes a significant concentration-dependent increase in eNOS protein expression by cultured human coronary artery endothelial cells. [1] Nifedipine antagonizes L-type Ca+ channels found throughout the cardiovascular system, but also blocks Kv channels, which are members of the same supergene family. [2] Nifedipine dose-dependently decreases the values of [(3)H]-thymidine incorporation and total cellular protein content as well as the levels of phosphorylated extracellular signal-regulated protein kinase (ERK) 1/2, mitogen-activated protein kinase kinase (MEK) 1/2, and even the phosphorylation of Pyk2, in vascular smooth muscle cells (VSMC). Nifedipine suppresses the levels of proliferative cell nuclear antigen (PCNA) dose-dependently in both VSMC and balloon-injured thoracic aortae in VSMC. [3]
In Vivo
In vivo Nifedipine (3 mg/kg) slightly lowers the level of systolic and/or diastolic blood pressure or increased the heart rate in rats. [3] Nifedipine (1 μm) produces a maximal inhibition of the store-operated pathway in choroidal arteriolar smooth muscle. [4] Nifedipine (20 and 40 mg/kg) markedly prevents the HCl plus ethanol-induced gastric mucosal injury and the increase in the content of thiobarbituric acid-reactive substances in the injured mucosa in rats. Nifedipine (20 and 40 mg/kg) dose-dependently promotes the ulcer healing and inhibites the increase in the content of thiobarbituric acid-reactive substances in the ulcerated mucosa in rats. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05096728 Completed
Preeclampsia With Severe Features
Ohio State University
 December 1 2021 --
NCT04392375 Completed
Preeclampsia Severe
Ohio State University
 June 9 2020 Phase 4
NCT03695107 Unknown status
Chronic Kidney Diseases
The Third Xiangya Hospital of Central South University
 October 2 2019 --
NCT02902354 Withdrawn
Tocolysis With Nifedipine
St. Louis University
 September 2016 Not Applicable
NCT03710395 Unknown status
Drug Transporter
Natalia Valadares de Moraes|Hospital das Clínicas de Ribeirão Preto|Universidade Estadual Paulista Júlio de Mesquita Filho
 December 14 2015 Phase 4

Chemical Information & Solubility

Molecular Weight 346.33 Formula

C17H18N2O6
CAS No. 21829-25-4 SDF Download Nifedipine SDF
Smiles CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
Storage (From the date of receipt) 2 years 4°C(in the dark) powder

In vitro
Batch:

DMSO : 69 mg/mL ( (199.23 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 15 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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