Home Neuronal Signaling Adrenergic Receptor agonist Vilanterol Trifenate For research use only.

Vilanterol Trifenate

Synonyms: GW642444M Trifenate

Vilanterol trifenatate (GW642444M) is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.

Vilanterol Trifenate Chemical Structure

Vilanterol Trifenate Chemical Structure

CAS No. 503070-58-4

Purity & Quality Control

Vilanterol Trifenate Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Vilanterol trifenatate (GW642444M) is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.
Targets
β2-adrenoceptor [1]
In vitro
In vitro Vilanterol displays a subnanomolar affinity for the β2-AR that is comparable with that of salmeterol but higher than olodaterol, formoterol, and indacaterol. In cAMP functional activity studies, vilanterol demonstrates similar selectivity as salmeterol for β2- over β1-AR and β3-AR, but a significantly improved selectivity profile than formoterol and indacaterol. Vilanterol also shows a level of intrinsic efficacy that is comparable to indacaterol but significantly greater than that of salmeterol. In cellular cAMP production and tissue-based studies measuring persistence and reassertion, vilanterol has a persistence of action comparable with indacaterol and longer than formoterol. In addition, vilanterol demonstrates reassertion activity in both cell and tissue systems that is comparable with salmeterol and indacaterol but longer than formoterol. In human airways, vilanterol is shown to have a faster onset and longer duration of action than salmeterol, exhibiting a significant level of bronchodilation 22 h after treatment[1].

Chemical Information & Solubility

Molecular Weight 774.77 Formula

C24H33Cl2NO5.C20H16O2
CAS No. 503070-58-4 SDF Download Vilanterol Trifenate SDF
Smiles OCC1=CC(=CC=C1O)C(O)CNCCCCCCOCCOCC2=C(Cl)C=CC=C2Cl.OC(=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (129.07 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 14 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Vilanterol Trifenate | Vilanterol Trifenate ic50 | Vilanterol Trifenate price | Vilanterol Trifenate cost | Vilanterol Trifenate solubility dmso | Vilanterol Trifenate purchase | Vilanterol Trifenate manufacturer | Vilanterol Trifenate research buy | Vilanterol Trifenate order | Vilanterol Trifenate mouse | Vilanterol Trifenate chemical structure | Vilanterol Trifenate mw | Vilanterol Trifenate molecular weight | Vilanterol Trifenate datasheet | Vilanterol Trifenate supplier | Vilanterol Trifenate in vitro | Vilanterol Trifenate cell line | Vilanterol Trifenate concentration | Vilanterol Trifenate nmr