Home Neuronal Signaling Adrenergic Receptor antagonist - 5-HT Receptor agonist Urapidil For research use only.

Urapidil

Urapidil is an antihypertensive drug acting as an α1 adrenoreceptor antagonist and a 5-HT1A agonist.

Urapidil Chemical Structure

Urapidil Chemical Structure

CAS No. 34661-75-1

Purity & Quality Control

Batch: S596501 DMSO]77 mg/mL]false]Ethanol]77 mg/mL]false]Water]Insoluble]false Purity: 99.95%
99.95

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Biological Activity

Description Urapidil is an antihypertensive drug acting as an α1 adrenoreceptor antagonist and a 5-HT1A agonist.
Targets
α1 adrenoreceptor [1] 5-HT1A [1]
In Vivo
In vivo

Urapidil alleviates ovarian torsion detorsion injury via regulating oxidative stress, apoptosis, autophagia, and inflammation.[2]
Animal Research Animal Models female Wistar albino rats
Dosages 0.5 mg/kg, 5 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03076099 Unknown status
Anesthesia
Nan Jiang|First Affiliated Hospital Sun Yat-Sen University
 January 1 2016 Not Applicable
NCT05537194 Completed
Hypoxia
University Hospital Caen
 January 1 1963 --

Chemical Information & Solubility

Molecular Weight 387.48 Formula

C20H29N5O3
CAS No. 34661-75-1 SDF --
Smiles COC1=CC=CC=C1N2CCN(CCCNC3=CC(=O)N(C)C(=O)N3C)CC2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 77 mg/mL ( (198.71 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 77 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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