Home Neuronal Signaling Adrenergic Receptor antagonist Tolazoline HCl For research use only.

Tolazoline HCl

Synonyms: Imidaline hydrochloride,NSC35110 hydrochloride

Tolazoline(Imidaline hydrochloride,NSC35110 hydrochloride) is a non-selective competitive α-adrenergic receptor antagonist.

Tolazoline HCl Chemical Structure

Tolazoline HCl Chemical Structure

CAS No. 59-97-2

Purity & Quality Control

Batch: S412401 DMSO]39 mg/mL]false]Water]39 mg/mL]false]Ethanol]39 mg/mL]false Purity: 99.88%
99.88

Tolazoline HCl Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Tolazoline(Imidaline hydrochloride,NSC35110 hydrochloride) is a non-selective competitive α-adrenergic receptor antagonist.
Targets
α-adrenergic receptor [1]
In vitro
In vitro

Tolazoline is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN). Tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Tolazoline usually reduces pulmonary arterial pressure and vascular resistance.[1] Tolazoline is not as broadly effective as SNP against all spasmogens investigated. However, it may be effective in counteracting alpha-adrenoceptor-mediated vasospasm in human radial arteries. [2]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00574184 Completed
Erectile Dysfunction
University of California Davis
 August 2005 --

Chemical Information & Solubility

Molecular Weight 196.68 Formula

C10H12N2.HCl
CAS No. 59-97-2 SDF Download Tolazoline HCl SDF
Smiles C1CN=C(N1)CC2=CC=CC=C2.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 39 mg/mL ( (198.29 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 39 mg/mL

Ethanol : 39 mg/mL


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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